A SUBSET OF CB002 XANTHINE ANALOGS BYPASS P53-SIGNALING TO RESTORE A P53 TRANSCRIPTOME AND TARGET AN S-PHASE CELL CYCLE CHECKPOINT IN TUMORS WITH MUTATED-P53

Mutations in TP53 occur commonly in the majority of human tumors and confer aggressive tumor phenotypes, including metastasis and therapy resistance.CB002 and structural-analogs restore p53 signaling in tumors with mutant-p53 but we find that unlike other xanthines such as caffeine, pentoxifylline, and theophylline, they do not deregulate the G2 ch

Since the implementation of China’s afforestation and conservation projects during recent decades, an increasing number of studies have reported greening trends in the karst Bullet Valve regions of southwest China using coarse-resolution satellite imagery, but small-scale changes in the heterogenous landscapes remain largely unknown.Focusing

Leiomyomas are rare benign tumours of the oesophagus that remain silent in more than 50% of the cases.Giant leiomyomas measuring more than 5 cm are very rare.A Bullet Valve 47-year-old female presented with chest pain, cough and dysphagia for two months.Imaging studies were indicative of a 12.1x11.9 cm mass lesion in the distal oesophagus, CT guide

Many studies on reptiles have been conducted across Madagascar but some areas are poorly known in terms of the diversity Lung Health of reptiles such as the Bobaomby Complex in the northern tip of Madagascar.In February and March 2018, we conducted a biodiversity survey within five sites.This biological survey is to collect scientific information f

This paper addresses an autonomous navigation method for the autonomous underwater vehicle (AUV) C-Ranger applying information-filter-based simultaneous localization and Duster mapping (SLAM), and its sea trial experiments in Tuandao Bay (Shangdong Province, P.R.China).Weak links in the information matrix in an extended information filter (EIF) can